Current Lab Members
Steve Royle | Principal Investigator
I am a Senior Research Fellow for Cancer Research UK and an Associate Professor at Warwick Medical School. I did my undergrad at University of Sheffield and my PhD in the Department of Pharmacology at University of Cambridge. I did a post-doc with Leon Lagnado at the MRC Laboratory of Molecular Biology and started my own group in 2006/7 at Liverpool, moving the lab to Warwick in 2013.
Ellis Ryan | Postdoc
My project is to chacterise the proteins in the mesh which hold K-fibres together. I finsihed my PhD in Cancer Sciences in Birmingham with Roger Grand.
Nuria Ferrandiz | Postdoc
I am working on chromosome missegregation mechanisms in mitosis. Before joining the lab I worked with Enrique Martinez-Perez at MRC-CSC on chromosome segregation in oocytes.
Nicholas Clarke | PhD student
I am investigating the role of intermicrotubule bridges in kinetochore fibre stability. Prior to starting my PhD in the Royle lab, I studied at University of Leicester.
Gabrielle Larocque | PhD student
I am researching membrane trafficking and cell division. My work is supported by a Chancellor's Scholarship and an award from FQRNT. Previously I worked in the lab of Valérie Legendre-Guillemin at Université du Québec à Chicoutimi.
Joseph Dunford | Masters student
My project is on developing new tagging technologies for CLEM.
Anika Patel | Research Assistant
I am helping lots of projects in the lab, doing gene editing and make cell lines. Before coming here I did a Masters at Birmingham.
Royle Lab Alumni
Laura Wood | IAS-MRC DTP Fellow
I made a synthetic system for triggering endocytosis in human cells. I did my PhD in the Royle lab and then stayed on for a short postdoc.
Next | Post-doc, Bath, UK.
Cristina Gutiérrez Caballero | Postdoc
I worked on the role of microtubule crosslinkers in the stability of mitotic spindles and kinetochore fibres in particular.
Next | Exonate, Nottingham, UK.
Sourav Sarkar | Postdoc
I worked on FGFR3-TACC3 fusions in bladder cancer cells and the effect of this fusion on chromosome segregation.
Next | AstraZeneca, Cambridge, UK.
Aditi Kibe | Research Assistant
I helped generate tagged cell lines using CRISPR/Cas9 as well as keeping the lab running.
Next | PhD on MIBTP programme.
Georgina Starling | Research Assistant
I used 3View and 3D rendering to look at mitotic spindles at high resolution.
Next | PhD in Sheffield with Jason King.
Faye Nixon | PhD Student
I used 3D EM to characterise the mesh in kinetochore fibres of the mitotic spindle.
Next | Working for the NHS in NW England.
Rachel Jones | Research Assistant
I supported people in the lab working on mitotic spindle stability.
Next | PhD with Grant Stewart, Birmingham.
Satdip Kaur | Postdoc
I worked on the regulation of clathrin-mediated endocytosis during mitosis and on moonlighting functions for membrane trafficking proteins.
Next | Pastures new.
Leanna Smith | MIBTP Student
I came to the Royle lab for a rotation project during my Masters year of the BBSRC-funded MIBTP PhD programme. My project was to generate mutants in cancer relevant spindle proteins using CRISPR/Cas9.
Next | Miniproject with Richard Bayliss, Leicester.
Hamdi Hussain | MOAC Student
I am on the EPSRC-funded Molecular Organisation and Assembly in Cells (MOAC) programme. My project in the Royle lab was to engineer tagged versions of spindle and kinetochore proteins for ding knocksideways experiments.
Next | Miniproject with Andrew McAinsh.
Cecilia Velasco Dominguez | ERASMUS student
I was an undergraduate student from Barcelona when I visited the Royle Lab for a 6-month project on membrane trafficking. Previously, I did a research project with Artur Llobet at IDIBELL on synaptic vesicle recycling.
Next | Back to Barcelona to finish her degree.
Liam Cheeseman | PhD student
Liam did his PhD in the lab between 2010-2013. He used knocksideways to rapidly remove proteins from mitotic spindles.
Next | Postdoc with Melina Schuh, MRC-LMB.
Oliver Sinfield | Rotation student
Ollie's 12-week project in the lab was to investigate a potential link between membrane trafficking and cancer.
Next | PhD in Life Sciences, Warwick.
Andrew Fielding | Postdoc
Andrew worked on the regulation of clathrin-mediated endocytosis during the cell cycle. He worked in the lab between Dec 2010-Jan 2013.
Next | Postdoc with Judy Coulson, University of Liverpool.
Gisela Gassner | ERASMUS student
Gisela came to the lab from FH Krems, Austria for a placement (Jul 12-Jan 13). She worked with Andrew on CME regulation during mitosis.
Next | Back to Austria to finish her degree.
Fiona Hood | Postdoc
Fiona worked in the Royle lab from Dec 2007-Dec 2012. She purified the TACC3/ch-TOG/clathrin complex from mitotic spindles and worked out how the complex sticks together and to microtubules.
Next | Postdoc with Ian Prior at the University of Liverpool.
Samantha Williams | Research Technician
Sam worked in the lab from Nov 10-Aug 12. She worked on aurora A regulation of TACC3-clathrin binding.
Next | PhD with Ana Losada, CNIO, Madrid.
Yasmina Sahraoui | Summer student
Yasmina worked on clathrin-adaptor interactions during the summer of 2012.
Next | Finishing her degree at University of Liverpool.
Anna Korniejewska Willox | Postdoc
Anna worked on synaptic vesicle recycling and identified stonin-2 as a major adaptor protein at the synapse. She worked in the lab Nov 08-Mar 12.
Next | Working at KWS Biotest, Bristol.
Daniel Booth | PhD Student
Dan did his PhD with Steve and Ian from Oct 08-Oct 11. He got correlative light-electron microscopy working in the lab and showed microtubule crosslinks contain clathrin.
Next | Postdoc with Bill Earnshaw, Wellcome Trust Centre for Cell Biology, Edinburgh.
Maria Blixt | Research Technician
Maria worked in the lab from Nov 08-Nov 10. She worked on gene fusions involving clathrin heavy chain expressed in human cancers.
Next | PhD at Uppsala Universitet, Sweden.
Other folks that have worked with us:
Hannah Dunford | Research Technician (Sep 07-Aug 08).
All of the following rotation students:
(2013-on): Curtis Oliver-Smith.
(pre-2013): Hannah McCue, Liyi Wang, Kelly Robinson, Emmanuel Okeke, Anna Newlaczyl, Dayani Rajamanoharan and Joanna Wardyn.
Royle Lab Map
This is a chart to show where in the world all the Royle Lab members (past and present) have originated.
Ian Prior | University of Liverpool
Ian and Steve have worked together for several years. They have co-supervised three PhD students together in projects that involved electron microscopy. Ian has a lab at University of Liverpool and also is the academic lead of the EM Unit in Liverpool.
Richard Bayliss | University of Leicester
Richard is a structural biologist in the Department of Biochemistry, University of Leicester. His research interests are centred around protein kinases, particularly the mitotic kinase Aurora A. We are collaborating with Richard on the structure of TACC3/ch-TOG/clathrin complex. TACC3 is a well-known Aurora A substrate and this phosphorylation governs its interaction with clathrin.
Artur Llobet | Universitat de Barcelona
Artur is a neuroscientist interested in synaptic transmission and plasticity. His lab are experts in highly specialised experiments such as correlative electrophysiology, imaging and EM. They use autaptic microisland culture systems and more recently Xenopus sensory neurons. We have teamed up with the Llobet lab to investigate the role of clathrin in presynaptic physiology and plasticity.
Andrew Fry | University of Leicester
Andrew's lab is based in the Department of Biochemistry, University of Leicester. His group is interested in centrosomes and cancer, particularly a group of kinases (Neks) and the proteins they regulate throughout the cell cycle. We recently worked with them on a project looking at Hsp72 (regulated by Nek6) and K-fibre stability.
> We are collaborating with other labs in Warwick, Cambridge and elsewhere in the world.
Royle Lab Jobs
> We are currently looking for post-docs!
Membrane traffic, cell migration, cancer | Post-doc position
The lab focusses on cell biology at the molecular level with projects on cell division, membrane traffic, cell migration and cancer.
The aim of this project funded by MRC, is to understand the membrane trafficking functions of Tumor Protein D52-like proteins and their role in cell migration/invasion.
The expression of these proteins is altered in cancer and their overexpression correlates with poor prognosis. We use imaging (light and electron microscopy), biochemistry, and gene editing to understand molecular mechanisms in human cells.
We offer an outstanding environment for discovery science in one of the best universities in the UK.
Feel free to get in touch if you need more information.
. Closing 8th June 2017
If you are a bright, enthusiastic person interested in the work we do, we would like to hear from you.
Vacancies will come up from time-to-time and will be advertised here, on jobs.ac.uk and on Naturejobs. There are several sources for fellowships to come and work in our lab: EMBO, Human Frontiers Science Program, Royal Society and Marie Curie. Contact us if you are interested.
There are two routes to come to the lab as a post-graduate student. Firstly, we host mini-project students from the various programmes in Warwick and these may developed into a full PhD research project. Secondly, students can come direct to the lab to start their PhD. There are currently several sources of funding for each of these possibilities. The lab participates in two MRes/PhD programmes: the MRC Doctoral Training Partnership, the Midlands Integrative Biosciences Training Partnership. Other possibilities are programmes in Synthetic Biology or Complexity. To come direct to the lab, funding can be obtained from an external source or from a Chancellor's International Studentship or WMS Scholarship. Deadlines for all of these are in January. Contact us if you are interested.
There may be opportunities for summer/vacation work in the lab. Contact us for details.
Royle Lab Fun... photos!
> Royle lab logo competition (August 2016) | view
> More fun in the Royle lab 2015 onwards | view
> Fun in the Royle Lab 2007-2014 | view
> See 2016 Nobel Laureate Bob Dylan explain Royle lab work | Subcellular Homesick Blues