Kinesin-driven transport along microtubules is a core mechanism of active self-organisation in eukaryotes. We are trying to understand how kinesin-microtubule systems generate force and movement, with the aim of understanding their molecular-level function in health and disease.
Rob Cross CV
Katsuki, M., Drummond, D.R. & Cross, R.A. (2014)
Ectopic A-lattice seams destabilise microtubules
Nature Communications [OPEN]
Wolman, A.J.M., Sanchez-Cano, C., Carstairs, H.M.J., Cross, R.A. & Turberfield, A.J. (2013)
Transport and self-organization across different length scales powered by motor proteins and programmed by DNA
Nature Nano DOI:10.1038/NNANO.2013.230 [Link]
Grant, B.J., Gheorghe, D., Zheng,W., Alonso, M., Huber, G., Dlugosz,M., McCammon, J.A. & Cross, R.A. (2011)
Electrostatically biased binding of kinesin to microtubules
PLOS Biology 9(11) e1001207. [pdf]
Alonso,M.C., Drummond, D.R., Kain, S., Hoeng, J., Amos, L.A. & Cross, R.A. (2007)
An ATP-gate controls tubulin binding by the tethered head of kinesin-1
Science 316 120-123 [pdf]
Carter N.J. & Cross R.A. (2005)
Mechanics of the kinesin step
Nature 435 308-12 [pdf]
>> Timeline of our contributions
I am interested in the molecular mechanisms by which tubulin changes conformation in response to nucleotide turnover and to the binding of small molecules and of kinesin. A major technique is tubulin mutagenesis in S. pombe.
I am a newly-appointed Research Assistant working on tubulin mutagenesis in the Cross lab. Funded by BBSRC.
XMAP215 proteins belong to a highly conserved family that promote microtubule growth by up to a factor of 10. I study the mechanism of two S. pombe TOG/XMAP215 homologues - Alp14 and Dis1.
Microtubules switch from slow growth to rapid depolymerisation via a process called catastrophe. I am interested in the molecular mechanisms that underpin microtubule stability and catastrophe.
I am interested in the single molecule mechanics of molecular motors and tracks. I am also designer and developer of the Warwick Open Source Microscope, an ultra stable open source platform for advanced optical microscopy.
I am looking into single molecule mechanochemistry of several kinesins from fission yeast and modelling their behaviour. I am funded by Warwick's MOAC DTC.
I am researching the single molecule behaviour of mitotic kinesins, using laser tweezers. I am funded by Warwick's Systems Biology DTC. My project is in collaboration with the McAinsh lab.
I am analysing and simulating the stepping behaviour of processive kinesins, aiming to make predictions of the behaviour of teams of kinesins. Funded by Warwick's Complexity Complex, cosupervisor Stefan Grosskinsky.
I am a fourth year Mathematics undergraduate, working on the crowd dynamics of bidirectional kinesins. Cosupervisor Robert McKay.