up-and-coming...

>> CANCELLED James Wakefield (University of Exeter, UK)

time & place: 2pm - Clinical Trials Unit, TM08-09, Gibbet Hill

Title to follow...

Abstract to follow...

...and previously

>> July 21 Marcus Braun (MPI-Dresden, Germany)

time & place: 2pm - Clinical Trials Unit, TM08-09, Gibbet Hill

Ase1 brakes kinesin-14-driven inter-microtubule sliding and stabilizes bipolar overlaps

Spatiotemporal self-organization of the microtubular cytoskeleton involves motorized inter-microtubule sliding. An important example is the mitotic cell division where in the central spindle motor proteins of the kinesin-5 and -14 families cross-link and slide anti-parallel microtubules relative to each other. In vitro reconstituted kinesin-5 and -14 motorized sliding continues until microtubules separate. In cells however, stable zones of overlap are formed between the ends of anti-parallel microtubules. This process requires non-motor microtubule cross-linkers of the Ase1/PRC1/M AP65 family, which are thought to counteract motorized sliding via protein friction....

>> June 16 Stan Burgess (Astbury Centre, University of Leeds)

time & place: 2pm - Clinical Trials Unit, Gibbet Hill

The dynein motor comes out of the cold - electron microscopy studies of an enigmatic motor protein

Dynein We are using electron microscopy (EM), including cryo-EM and single particle 3D reconstruction, to investigate the structure and mechanism of the Dynein motor protein. From these results we propose that ATP-dependent movement of the linker during dynein’s powerstroke involves a structural change within the linker itself rather than a rigid-body rotation of the entire linker.