Mechanobiology at the Shard 2018

A Randall Institute | CMCB joint symposium

05 February 2018

Organised by:

Rob Cross (Centre for Mechanochemical Cell Biology, Warwick Medical School)

Mathias Gautel (Randall Institute, Kings College London)


Work at our two institutions aims to understand the contributions of mechanical and mechanochemical mechanisms to cell function. To learn about each other's work and to facilitate progress, we have organised this one day joint Symposium in Molecular and Cellular Mechanobiology, with support from Wellcome and from the British Heart Foundation. We will discuss topics ranging from single molecule dynamics of molecular motors to the mechanics of muscle contraction and cell crawling.

Home | Participants | Registration | Photos from 2017

PROGRAMME - Monday 05 February 2018

Doors open to Kings / Randall contingent

Scheduled arrival of Warwick contingent

Welcome and introductory remarks
10:40 - 11:00 Luca Fusi  Stress-dependent activation of thick filaments controls the rate of force geenration in skeletal muscle
11:00 - 11:20
Nida Siddiqui Mechanochemical cell biology of Kif1C
11:20 - 11:40 Darius K√∂ster  Reconstitution of the cytokinetic ring machinery: Module by module
11:40 - 12:00 Daniel Brayson  Going nuclear in the cardiomyocyte: Investigating the role of prelamin A in heart disease
12:00 - 12:20 Elvira Infante  The Nuclear Pore Complex is a nanomechanical gate
12:30 - 13:30

13:30 - 13:40 Reza Razavi (Remarks)
13:40 - 14:00 Scott Clarke Dynamics of actomyosin in zebrafish early development
14:00 - 14:20 David Nordsletten Biomechanics and the hierarchical structure of the heart
14:20 - 14:40 Ralph Sinkus
Using acoustic waves to explore tissue mechanics and actively impact on cell proliferation and migration
14:40 - 15:00 Emanuele Roscioli
Force-dependent changes in the 3D architecture of a kinetochore
15:00 - 15:20 Phil Auckland
Mechanisms of chromosome congression
15:30 - 16:00

16:00 - 16:20 Nigel Burroughs  Modelling the spatial dynamics of kinetochores
16:20 - 16:40
Sharon Collier
Image based modelling of bleb site selection enzyme
16:40 - 17:00

Floor discussion
17:15 - 19:00

Evening Reception (Gordon Museum of Physiology)