Work in the lab focuses on the force generating mechanisms of kinesins and microtubules.
We are trying to understand the molecular mechanisms of mechanochemical coupling in kinesin-microtubule systems. These mechanisms drive much of the self-organisation behaviour of eukaryotic cells and understanding them is important both for fundamental science and for the development of improved chemical biology approaches to a range of important medical and agricultural problems.
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M. Britto, A. Goulet, S. Rizvi, O. von Loeffelholz, C. A. Moores, and R. A. Cross (2016)
Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism
PNAS DOI: 10.1073/pnas.1611581113
R.A. Cross (2016)
Mechanochemistry of the kinesin-1 ATPase
Biopolymers DOI: 10.1002/bip.22862
Frauke Hussmann, Douglas R. Drummond, Daniel Peet, Douglas S. Martin & Robert A. Cross (2016)
Alp7/TACC-Alp14/TOG generates long-lived, fast-growing MTs by an unconventional mechanism
Nature Scientific Reports DOI: 10.1038/srep20653
Joanna Andrecka, Jaime Ortega Arroyo, Katie Lewis, Robert A. Cross, and Philipp Kukura (2016)
Label-free Imaging of Microtubules with Sub-nm Precision Using Interferometric Scattering Microscopy
Biophysical Journal 110 214-217
I am a Research Assistant working on the mutagenesis and protein chemistry of tubulins.
Kinesin motors can influence microtubule dynamics. I am interested in understanding how this works.
I am interested in the single molecule mechanics of molecular motors and tracks. I am also designer and developer of the Warwick Open Source Microscope, an ultra stable open source platform for advanced optical microscopy.
I am analysing and simulating the stepping behaviour of processive kinesins, aiming to make predictions of the behaviour of teams of kinesins.
I am interested in the mechanics of bidirectional kinesins.
I made these movies!
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