Cross Lab


mechanochemistry mechanochemistry mechanochemistry mechanochemistry mechanochemistry mechanochemistry

Work in the lab focuses on the force generating mechanisms of kinesins and microtubules.

These mechanisms drive much of the active self-organisation behaviour of eukaryotic cells and understanding them is important both for fundamental science and for the development of improved chemical biology approaches to a range of important medical and agricultural problems.

CV | Google | Pubmed | UoW | WMS WiA



McHugh, T., Drechsler, H., McAinsh, A.D., Carter, N.J. & Cross R.A. (2018)
Kif15 functions as an active mechanical ratchet.
Mol Biol Cell. mbcE18030151. doi: 10.1091/mbc.E18-03-0151. [Link]

TOG domain MT polymerases accelerate MT plus end growth via electrostatically-steered diffusion-to-capture and electrostatic templating of GTP-tubulin
| Venables et al (2018) | bioRxiv

peet Daniel R. Peet, Nigel J Burroughs, Robert A. Cross (2018)
Kinesin expands and stabilises the GDP-microtubule lattice
| Nature Nano



Your Name Here | Kinesin-microtubule mechanochemistry

Open Postdoctoral Position Two year Wellcome funded postdoctoral position available, to work on the single molecule mechanics of kinesin molecular motors and their microtubule tracks.

>> Apply here <<

Naomi Sheppard | Tubulin mechanochemistry

I am a Research Assistant working on the mutagenesis and protein chemistry of tubulins.

Nick Carter | Advanced Microscopy

I am interested in the single molecule mechanics of molecular motors and tracks & am designer and developer of the WOSM.

Algirdas Toleikis | Bidirectionality

I am interested in the mechanics of bidirectional kinesins.

Charlotte Fletcher | Magnetic nanomanipulation

I am a PhD student, joint with the McAinsh lab, developing methods for magnetic nanomanipulation.

>> Cross Lab Alumni