Cross Lab

Rob



Work in the lab focuses on the force generating mechanisms of kinesins and microtubules.

We are trying to understand the molecular mechanisms of mechanochemical coupling in kinesin-microtubule systems. These mechanisms drive much of the self-organisation behaviour of eukaryotic cells and understanding them is important both for fundamental science and for the development of improved chemical biology approaches to a range of important medical and agricultural problems.

CV | Google scholar | Pubmed | UoW
WiA

 

M. Britto, A. Goulet, S. Rizvi, O. von Loeffelholz, C. A. Moores, and R. A. Cross (2016)
Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism

PNAS DOI: 10.1073/pnas.1611581113
[Open]


R.A. Cross (2016)
Mechanochemistry of the kinesin-1 ATPase

Biopolymers DOI: 10.1002/bip.22862
[Open]

 

Frauke Hussmann, Douglas R. Drummond, Daniel Peet, Douglas S. Martin & Robert A. Cross (2016)
Alp7/TACC-Alp14/TOG generates long-lived, fast-growing MTs by an unconventional mechanism

Nature Scientific Reports DOI: 10.1038/srep20653
[Open]


Joanna Andrecka, Jaime Ortega Arroyo, Katie Lewis, Robert A. Cross, and Philipp Kukura (2016)
Label-free Imaging of Microtubules with Sub-nm Precision Using Interferometric Scattering Microscopy

Biophysical Journal 110 214-217
[Link]


Naomi Sheppard | Tubulin mechanochemistry

I am a Research Assistant working on the mutagenesis and protein chemistry of tubulins.

Daniel Peet | Kinesins and microtubule dynamics

Kinesin motors can influence microtubule dynamics. I am interested in understanding how this works.

Nick Carter | Advanced Microscopy

I am interested in the single molecule mechanics of molecular motors and tracks. I am also designer and developer of the Warwick Open Source Microscope, an ultra stable open source platform for advanced optical microscopy.

Neil Jenkins | Kinesin crowds

I am analysing and simulating the stepping behaviour of processive kinesins, aiming to make predictions of the behaviour of teams of kinesins.

Algirdas Toleikis | Bidirectionality

I am interested in the mechanics of bidirectional kinesins.

Atreyi Chakrabarty | Intern

I made these movies!

 

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