Work in my lab focuses on the force generating mechanisms of kinesins and their microtubule tracks.
We are trying to understand the molecular mechanisms of mechanochemical coupling. These mechanisms drive much of the self-organisation behaviour of eukaryotic cells and understanding them is important both for fundamental science and for the development of improved chemical biology approaches to a range of important medical and agricultural problems.
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Katsuki, M., Drummond, D.R. & Cross, R.A. (2014)
Ectopic A-lattice seams destabilise microtubules
Nature Communications [OPEN]
Wolman, A.J.M., Sanchez-Cano, C., Carstairs, H.M.J., Cross, R.A. & Turberfield, A.J. (2014)
Transport and self-organization across different length scales powered by motor proteins and programmed by DNA
Nature Nano DOI:10.1038/NNANO.2013.230 [Link]
Grant, B.J., Gheorghe, D., Zheng,W., Alonso, M., Huber, G., Dlugosz,M., McCammon, J.A. & Cross, R.A. (2011)
Electrostatically biased binding of kinesin to microtubules
PLOS Biology 9(11) e1001207. [pdf]
Alonso,M.C., Drummond, D.R., Kain, S., Hoeng, J., Amos, L.A. & Cross, R.A. (2007)
An ATP-gate controls tubulin binding by the tethered head of kinesin-1
Science 316 120-123 [pdf]
Carter N.J. & Cross R.A. (2005)
Mechanics of the kinesin step
Nature 435 308-12 [pdf]
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I am interested in the molecular mechanisms by which tubulin changes conformation in response to nucleotide turnover and to the binding of small molecules and of kinesin. A major technique is tubulin mutagenesis in S. pombe.
I am a Research Assistant working on the mutagenesis and protein chemistry of tubulins.
XMAP215 proteins belong to a highly conserved family that promote microtubule growth by up to a factor of 10. I study the mechanism of two S. pombe TOG/XMAP215 homologues - Alp14 and Dis1.
Microtubules switch from slow growth to rapid depolymerisation via a process called catastrophe. I am interested in the molecular mechanisms that underpin microtubule stability and catastrophe.
I am interested in the single molecule mechanics of molecular motors and tracks. I am also designer and developer of the Warwick Open Source Microscope, an ultra stable open source platform for advanced optical microscopy.
I am looking into single molecule mechanochemistry of several kinesins from fission yeast and modelling their behaviour. I am funded by Warwick's MOAC DTC.
I am researching the single molecule behaviour of mitotic kinesins, using laser tweezers. I am funded by Warwick's Systems Biology DTC. My project is in collaboration with the McAinsh lab.
I am analysing and simulating the stepping behaviour of processive kinesins, aiming to make predictions of the behaviour of teams of kinesins. Funded by Warwick's Complexity Complex, cosupervisor Stefan Grosskinsky.