Work in the lab focuses on the force generating mechanisms of kinesins and microtubules.
These mechanisms drive much of the active self-organisation behaviour of eukaryotic cells and understanding them is important both for fundamental science and for the development of improved chemical biology approaches to a range of important medical and agricultural problems.
CV | Google scholar | Pubmed | UoW | WMS
McHugh T., Drechsler H., McAinsh A. D., Carter N. J. & Cross R. A. (2017)
Single molecule mechanics reveal Kif15 as an active molecular ratchet with acute strain sensitivity | BioRxiv
Daniel R. Peet, Nigel J Burroughs, Robert A. Cross (2017)
Structural-mechanical remodelling of GDP-microtubules by kinesin | BioRxiv
I am a Research Assistant working on the mutagenesis and protein chemistry of tubulins.
Kinesin motors can influence microtubule dynamics. I am interested in understanding how this works.
I am interested in the single molecule mechanics of molecular motors and tracks & am designer and developer of the WOSM.
I am analysing and simulating the stepping behaviour of teams of processive kinesins.
I am a PhD student, joint with the McAinsh lab, developing methods for magnetic nanomanipulation.