Mechanochemical Cell Biology
Cross Lab
Mishima Lab
McAinsh Lab
Straube Lab
McAinsh Lab
Mishima Lab
Royle Lab
Straube Lab
McAinsh Lab
Straube Lab
Cross Lab
Blanks Lab
Sampath Lab
Turner Lab
Spinning disk microscope...
Mechanochemical Cell Biology

NPYRFP Plain English CELLULAR HIGHWAYS - These vesicles are bags of cargo transported along microtubules inside living cells by tiny walking machines. New work from the Straube lab shows how KIF1C, one type of walking machine, is folded up and kept inactive when not loaded with cargo. PTPN21 and Hook3 are two activators that unfold KIF1C, allow it to engage with microtubules and start walking, dragging their cargo vesicles along.

[Link to Press Release]

 


KIF1CReady - Steady - Go!

We show how kinesin KIF1C is activated upon cargo binding.
>> Read the paper | [Link]

 

EBsBehind you...

Daniel and Ben reconstituted spatially distinct microtubule tracking of EBs in vitro.
>> Read the paper | [Link]

 

Liam&JohnBrief candles

John & Liam show that kinesin complexes queue at plus tips to trigger microtubule catastrophe at cell tips.
>> Read the paper | [Link]

Check it, Bub

Cerys shows that Bub1 is dispensible for the spindle assembly checkpoint.
>> Read the paper | [Link]

Tag team

Nick made a new tag for correlative light-electron microscopy called FerriTag.
>> Read the paper | [Link] | [Plain English]

Decompression stickness

Peet et al show that kinesin can reversibly expand and stabilise the lattice of GDP-microtubules.
>> Read the paper | [Link]

Pick ya actin

Tomo Hatano et al can now make any actin they like in Pichia Pastoralis >> Read the paper | [Link]

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