Cansu and others from the Royle lab show that clathrin-coated pits can be made to form inside cells. Even on mitochondria! This work reveals what are the essential ingredients to cook up a vesicle.
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Ubiquitin-linked ESCRT machinery, which participates in a wide variety of membrane remodelling events, was until recently considered a eukaryotic invention. Hatano and colleagues show that such a machinery existed prior to consolidation of the first eukaryotic common ancestor by investigating related ESCRT proteins and ubiquitin from ASGARD archaea. The work reveals structural and biochemical conservation and outlines potential steps in evolution leading to the present day ESCRT machinery >> Find out more [Paper]
Our weekly virtual seminar series on molecular motors.
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Our new series gives a platform to early career mechanochemical cell biologists to explain their science and then discuss with CMCB members. If we think you would be a good fit, we will support you in early career fellowship applications and in other ways.