CELLULAR HIGHWAYS - These vesicles are bags of cargo transported along microtubules inside living cells by tiny walking machines. New work from the Straube
lab shows how KIF1C, one type of walking machine, is folded up and kept inactive when not loaded with cargo. PTPN21 and Hook3 are two activators that unfold
KIF1C, allow it to engage with microtubules and start walking, dragging their cargo vesicles along.
Ready - Steady - Go!
We show how kinesin KIF1C is activated upon cargo binding.
>> Read the paper
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[Link]
Behind you...
Daniel and Ben reconstituted spatially distinct microtubule tracking of EBs in vitro.
>> Read the paper
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[Link]
Brief candles
John & Liam show that kinesin complexes queue at plus tips to trigger microtubule catastrophe at cell tips.
>> Read the paper
| [Link]
Check it, Bub
Cerys shows that Bub1 is dispensible for the spindle assembly checkpoint.
>> Read the paper
| [Link]
Tag team
Nick made a new tag for correlative light-electron microscopy called FerriTag.
>> Read the paper
| [Link] | [Plain English]
Decompression stickness
Peet et al show that kinesin can reversibly expand and stabilise the lattice of GDP-microtubules.
>> Read the paper
| [Link]
Pick ya actin
Tomo Hatano et al can now make any actin they like in Pichia Pastoralis
>> Read the paper
| [Link]
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