Ubiquitin-linked ESCRT machinery, which participates in a wide variety of membrane remodelling events, was until recently considered a eukaryotic invention. Hatano and colleagues show that such a machinery existed prior to consolidation of the first eukaryotic common ancestor by investigating related ESCRT proteins and ubiquitin from ASGARD archaea. The work reveals structural and biochemical conservation and outlines potential steps in evolution leading to the present day ESCRT machinery >> Find out more [Paper]
Nuria and others from the Royle Lab show how endomembranes can cause chromosome missegregation in mitosis.
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[Paper] [Plain English] [Spotlight]
Collaborative paper between Royle and Smith labs explains how adaptors drive clathrin coat assembly.
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[Paper] [Plain English]
Saravanan, Darius and colleagues show how to wind actin into tight rings.
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[Paper]
Our new series gives a platform to early career mechanochemical cell biologists to explain their science and then discuss with CMCB members. If we think you would be a good fit, we will support you in early career fellowship applications and in other ways.