Cross Lab

 

mechanochemistry mechanochemistry mechanochemistry mechanochemistry mechanochemistry mechanochemistry mechanochemistry

Work in the lab focuses on the force generating mechanisms of kinesins and microtubules.


These mechanisms drive much of the active self-organisation behaviour of eukaryotic cells and understanding them is important both for fundamental science and for the development of improved chemical biology approaches to a range of important medical and agricultural problems.


WiA

interface

O. Von Loeffelholz, A. Peña, D. R. Drummond, R. Cross, C. A. Moores (2019)
4.5 Å Cryo-EM Structure of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance [Link]

toni

McHugh, T., Drechsler, H., McAinsh, A.D., Carter, N.J. & Cross R.A. (2018)
Kif15 functions as an active mechanical ratchet.
Mol Biol Cell. mbcE18030151. doi: 10.1091/mbc.E18-03-0151. [Link]


peet
TOG domain MT polymerases accelerate MT plus end growth via electrostatically-steered diffusion-to-capture and electrostatic templating of GTP-tubulin
| Venables et al (2018) | bioRxiv


peet Daniel R. Peet, Nigel J Burroughs, Robert A. Cross (2018)
Kinesin expands and stabilises the GDP-microtubule lattice
| Nature Nano

 

Rob Cross | Kinesin & tubulin

I lead the Motors Group and am also Director of the CMCB and Director of the Hooke Science Programme, our radical new undergraduate course in Integrated Science.


Google | Pubmed | UoW | WMS | New Lattice allostery

 

Nick Carter | Advanced Microscopy

I am interested in the single molecule mechanics of molecular motors and tracks & am designer and developer of the WOSM.

Algirdas Toleikis | Bidirectionality

I am interested in the mechanics of bidirectional kinesins.

Douglas Martin | eduWOSM

I am a scientific visitor to the Cross lab, working with Nick Carter and Claire Mitchell to develop the WOSM.

Yean Ming Chew | Microtubule lattice plasticity

I am a PhD student, working on tubulin engineering and microtubule lattice mechanics.

Huong Vu | Kinesin mechanism

I am a biophysicist, interested in how kinesins step.



>> Cross Lab Alumni