Research

Research Interests

Our research spans over multiple scales of organization: we explore biochemical and mechanical signalling pathways at tissue, cellular and gene expression levels with the ultimate aim to link these events in space and time. We focus our efforts on developmental processes that regulate tissue and organ formation during early zebrafish development including tissue morphogenesis, cell fate specification and tissue patterning, collective cell migration, cell adhesion, nuclear mechanics and gene expression.


research

Research Methods

Our research encompasses methodologies and technologies such as:

  • quantitative live imaging (confocal, multiphoton, light sheet microscopy)
  • optogenetics
  • embryological methods (ISH, transplantations)
  • in vitro reconstitution assays (micropatterning, supported lipid bilayers)
  • biophysical tools (microfluidics, laser ablation)
  • transcriptomics (scRNA sequencing, multiplexed smFISH)
  • gene editing (Crispr/Cas9)
  • theoretical modelling (collective motion, biomechanics)

Current Collaborators

Our projects are highly interdisciplinary and we are working closely with national and international collaborators including:
Till Brettschneider (Warwick Computer Science) | Computational Image Analysis
Melikhan Tanyeri (Duquesne University, US), Vasily Kantsler (Warwick Physics) | Microfluidics, Microfabrication
Kok Hao Chen (Singapore Genomic Institute) | Transcriptomics
Darius Koester (Warwick Medical School) | Membrane Biophysics
Matthew Turner (Warwick Physics) | Modelling
Verena Ruprecht (CRG Barcelona, ES) | Cell Migration
Anne Straube (Warwick Medical School) | Microtubule dynamics

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