mechanochemistry

 


The mission of the Centre for Mechanochemical Cell Biology at Warwick is to discover the molecular and cellular mechanisms driving active self-organisation in living systems. Our unique Centre was launched in 2010 and has grown meanwhile from 3 to 8 PIs, including three Wellcome Senior Investigators. The centre is housed in a purpose-designed building that was opened by Sir Paul Nurse in 2012. An extension is under construction and will open in 2016.

 

meiosismeiotic kinetochores

Jess Patel reveals how kinetochores operate differently during meiosis in humans and how this may explain chromosome errors as maternal age increases.
>> Biology Open (2015) | open access

inferthe force awakens

Burroughs and McAinsh use mathematical modelling to infer the forces controlling kinetochore motion.
>> PLOS Computational Biology (2015) | open access

superSuper Track

Burroughs and McAinsh reveal how a force-sensitive molecular clock controls direction of kinetochore movements - a key requirement for chromosome positioning.
>> eLife (2015) | link

bundleWalking home

The Mishima lab shows that cells link PRC1 to centralspindlin to create a motorised crosslinker that actively maintains the integrity of the central spindle.
>> Nature Communications (2015) | link

bundleThe Mesh

Discovery of a meshwork of inter-microtubule connectors in kinetochore fibres of the mitotic spindle by the Royle lab.

>> eLife (2015) | link | blog

ebincoherent sisters

McAinsh and Burroughs groups develop image analysis tools and live imaging to reveal how microtubule polymerisation is coordinated at sister kinetochores
>> Journal of Cell Science (2015) | Open Access PDF