mechanochemistry

 


The mission of the Centre for Mechanochemical Cell Biology at Warwick is to discover the molecular and cellular mechanisms driving active self-organisation in living systems. Our unique Centre was launched in 2010 and has grown meanwhile from 3 to 14 PIs, including 4 Wellcome Investigators.
Our centre is based in a purpose-designed building that was opened by Sir Paul Nurse in 2012. An extension was opened by Randy Schekman in August 2016.

 

curvCrowdsourced directionality

Britto et al show that yeast kinesin 5 has a proximity-sensor that sets its stepping direction.
>> PNAS (2016) | [Open Access]

curvBundled out

Balasubramanian lab find that cytokinetic rings expel bundles in response to changes in curvature
>> eLife (2016) | [Open Access]

swivswivel-eyed kinetochores

Collaboration between McAinsh and Burroughs reveals a new mechanical feature of the human kinetochore.
>> eLife (2016) | [Open Access]

kif15motor slide

Drechsler and McAinsh reveal that Kif15 is a multi-function motor that can rearrange microtubule networks, track plus-ends and control dynamics.
>> PNAS (2016) | [Open Access]

Alp14Faster, stronger

A Cross lab team show how the Alp7/14 tip-tracker accelerates microtubule plus end growth.
>> Nature Scientific Reports (2016) | [Open Access]

meiosismeiotic kinetochores

Jess Patel reveals how kinetochores operate differently during meiosis in humans and how this may explain chromosome errors as maternal age increases.
>> Biology Open (2015) | open access