centre for mechanochemical cell biology
our work asks about biophysical and cell-biological
mechanisms of motorized self-organization in cells.
more here
Dancing partners
We reveal the kinetochore components involved in corrdinating microtubule dynamics
>> Nature Cell Biology, 12 319-329 2010 | e-print
!NEW! see mini-review on this work, by Stukenberg and Foltz:
Kinetochores: Orchestrating the Chromosomal Minuet
Current Biology, 20: R522, 2010
Keeping track!
along with the Danuser, Swedlow and Meraldi labs we automatically track sister kinetochores in metaphase
>> Journal of Cell Biology, 188 665-79 2010 | e-print
EinMal ist keinMal
Miho shows definitively that Mal3 inhibits shrinkage and accelerates rescue - but does not affect catastrophe.
>> J. Biol. Chem., 23 29246-50 2009 | e-print
Bundle worker
Marcus showed that kinesin-14 actively sorts microtubules into parallel bundles.
>> Nature Cell Biology 11 724-30, 2009 | e-print
How the CMCB came to be
Jan 2010 | The idea for the CMCB had a lengthy gestation, but then was born quite suddenly one rainy day in March last year, when we learned > more here
The new CMCB building
3 Mar 2010 | The Wolfson Foundation have agreed to provide £1 million towards the construction of the new WMS Centre for Mechanochemical Cell Biology (CMCB) on the University's Gibbet Hill site. The contribution from the Wolfson Foundation brings the total build budget to £6.4 million, with £3.4 million > more here
The AMDU has two defining roles, to develop advanced microscope technology and to provide access to advanced microscope technology.
>> more here
>> August 25 !NEW! We welcome Mishan Britto who has begun life as a postdoc in the Cross laboratory - Mishan is funded by Marie Curie Cancer Care.
>> July 24 !NEW! warwick imaging portal now live...
>> July 22 Jack Heal, from the MOAC DTC, starts his third mini-project in the Cross lab.
>> July 21 Marcus Braun (MPI-Dresden, Germany)
time & place: 2pm - Clinical Trials Unit, TM08-09, Gibbet Hill
>> July 16 Andrew talk at workshop on Spatio-temporal Dynamics: Challenges in Biological Fluorescence Data, Warwick Mathematics Institute
>> July 9 ...first website development meeting in the AMDU...
>> June 16 Stan Burgess (Astbury Centre, University of Leeds)
time & place: 2pm - Clinical Trials Unit, Gibbet Hill
The dynein motor comes out of the cold - electron microscopy studies of an enigmatic motor protein
Dynein We are using electron microscopy (EM), including cryo-EM and single particle 3D reconstruction, to investigate the structure
and mechanism of the Dynein motor protein. From these results we propose that
ATP-dependent movement of the linker
during dynein’s powerstroke involves a structural change within the linker
itself rather than a rigid-body rotation of the entire
linker.
>> June 10 CMCB group leader retreat at Stratford Butterfly Farm
>> June 2 We welcome Elina Vladimirou who has begun life as a postdoc in the McAinsh laboratory - Elina is interested in understanding the mechanics of chromosome directional instability during anaphase.
>> May 28-29 The 5th McAinsh-Meraldi joint lab retreat took place in sunny Warwick.
>> May 19 Rob Cross (CMCB) Warwick Mathematics network seminar Kinesin-microtubule networks: natural, motorized, nanometer-scale transport
>> May 12 Helfrid Hochegger / Ewan Smith (MRC centre for genome damage & stability, Sussex University)
>> May 05 Carolyn Moores (Birkbeck College)
>> Apr 16 Rob's birthday (Cake @ 11:00)
>> Apr 13 Rob's keynote lecture to MOAC inter-DTC conference 11:00 H052
>> Apr 12-16 BSCB / BSDB joint annual meeting Warwick
>> Apr 6 3-labs meeting Rob & Maria 13:00 TM1 T0.09
>> Mar 29: Rob just back from international molecular motors meeting in Alpbach in the Austrian Tyrol.
>> Mar 22 Our new MOAC / sys biol students Dan Ed & Ali start work.
>> Mar 15 Rob in Paris, review cell bio section of Inst Curie
>> Coming shortly: Collaborators pages; Warwick bioimaging portal; science outreach page CMCBeebies; plain english versions of our papers.
The University of Warwick, Coventry, CV4 7AL, United Kingdom.
