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bundleWalking home

The Mishima lab shows that cells link PRC1 to centralspindlin to create a motorised crosslinker that actively maintains the integrity of the central spindle.
>> Nature Communications (2015) | link

bundleThe Mesh

Discovery of a meshwork of inter-microtubule connectors in kinetochore fibres of the mitotic spindle by the Royle lab.

>> eLife (2015) | link | blog

ebincoherent sisters

McAinsh and Burroughs groups develop image analysis tools and live imaging to reveal how microtubule polymerisation is coordinated at sister kinetochores
>> Journal of Cell Science (2015) | Open Access PDF

csp_afmSplitting heads

The Mishima lab shows that CYK4 binds to the neck domains of MKLP1, thereby configuring the heads for antiparallel microtubule bundling.
>> PLoS Biology (2015) | link

MAP4 Microtubule zipper

The Straube lab shows how MAP4 organises microtubules in muscle cells. oMAP4 is a microtubule zippering protein that controls motor-driven microtubule sliding.
>> eLife (2015) | link

cometsFinding the positives

Cristina in the Royle lab shows that TACC3 tracks the plus ends of microtubules together with ch-TOG.

>> Biology Open (2015) | link | blog

polarchrGetting aligned

McAinsh lab reveal how CENP-Q and the CENP-E motor coordinate chromosome congression during mitosis.

>> Journal of Cell Science (2015) | Open Access PDF

podosomesMaking contact

Straube and Kaverina labs show that Kif1C and CLASPs are required to form podosomes in vascular smooth muscle cells.
>> Journal of Cell Science (2014) | link | commentary

autapseGetting depressed

Work from Steve Royle and the Llobet lab in Barcelona shows that clathrin levels set presynaptic function and that their run-down contributes to synaptic depression.
>> Journal of Neuroscience (2014) | link | blog

pistopCaution: Pitstop

Testing the extent of non-specificity of the clathrin inhibitor Pitstop in clathrin-mediated endocytosis by the Royle lab.

>> Biology Open (2014) | link | blog