The mission of the Centre for Mechanochemical Cell Biology at Warwick is to discover the molecular and cellular mechanisms driving active self-organisation in living systems. Our unique Centre was launched in 2010 and has grown meanwhile from 3 to 8 PIs, including three Wellcome Senior Investigators. The centre is housed in a purpose-designed building that was opened by Sir Paul Nurse in 2012. An extension is under construction and will open in 2016.


superSuper Track

Burroughs and McAinsh reveal how a force-sensitive molecular clock controls direction of kinetochore movements - a key requirement for chromosome positioning.
>> eLife (2015) | link

bundleWalking home

The Mishima lab shows that cells link PRC1 to centralspindlin to create a motorised crosslinker that actively maintains the integrity of the central spindle.
>> Nature Communications (2015) | link

bundleThe Mesh

Discovery of a meshwork of inter-microtubule connectors in kinetochore fibres of the mitotic spindle by the Royle lab.

>> eLife (2015) | link | blog

ebincoherent sisters

McAinsh and Burroughs groups develop image analysis tools and live imaging to reveal how microtubule polymerisation is coordinated at sister kinetochores
>> Journal of Cell Science (2015) | Open Access PDF

csp_afmSplitting heads

The Mishima lab shows that CYK4 binds to the neck domains of MKLP1, thereby configuring the heads for antiparallel microtubule bundling.
>> PLoS Biology (2015) | link

MAP4 Microtubule zipper

The Straube lab shows how MAP4 organises microtubules in muscle cells. oMAP4 is a microtubule zippering protein that controls motor-driven microtubule sliding.
>> eLife (2015) | link