mechanochemistry

 


The mission of the Centre for Mechanochemical Cell Biology at Warwick is to discover the molecular and cellular mechanisms driving active self-organisation in living systems. Our unique Centre was launched in 2010 and has grown meanwhile from 3 to 14 PIs, including 4 Wellcome Investigators.
Our centre is based in a purpose-designed building that was opened by Sir Paul Nurse in 2012. An extension was opened by Randy Schekman in August 2016.

 

When the checkpoint is no longer Mad2

Millar lab report on a Mad2-independent checkpoint in fission yeast mitosis.
>> Cell Reports (2017) | [Open Access]

curvCrowdsourced directionality

Britto et al show that yeast kinesin 5 has a proximity-sensor that sets its stepping direction.
>> PNAS (2016) | [Open Access]

curvBundled out

Balasubramanian lab find that cytokinetic rings expel bundles in response to changes in curvature
>> eLife (2016) | [Open Access]

swivswivel-eyed kinetochores

Collaboration between McAinsh and Burroughs reveals a new mechanical feature of the human kinetochore.
>> eLife (2016) | [Open Access]

kif15motor slide

Drechsler and McAinsh reveal that Kif15 is a multi-function motor that can rearrange microtubule networks, track plus-ends and control dynamics.
>> PNAS (2016) | [Open Access]

Alp14Faster, stronger

A Cross lab team show how the Alp7/14 tip-tracker accelerates microtubule plus end growth.
>> Nature Scientific Reports (2016) | [Open Access]