blanks Research summary

My work focuses on the mechanisms of reproduction in mammals. In particular I am interested in how the uterine muscle develops and changes during gestation such that it can expel a healthy fetus at the right time.
My work can be divided into three areas:
1) Fundamental understanding of the electrical signals produced by cells utilizing a combination of experimentation, computation and mathematical modeling
2) Understanding the mechanisms of diseases associated with dysfunction of labour in humans, such as when babies are born too early and when the uterus fails to contract properly
3) Discovering new drugs to treat these diseases and helping to develop new therapies in partnership with pharmaceutical companies.

 

> Faculty page is here.

 

 

Atia et al. (2016) Reconstruction of cell surface densities of ion pumps, exchangers, and channels from mRNA expression, conductance kinetics, whole-cell calcium, and current-clamp voltage recordings, with an application to human uterine smooth muscle cells.
PLoS Computational Biology, 12(4):e1004828.

McCloskey et al. (2014) The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy.
EMBO Mol Med. 6(9):1161-74.

Sheldon et al. (2014) Alterations in gap junction connexin43/connexin45 ratio mediate a transition from quiescence to excitation in a mathematical model of the myometrium.
J R Soc Interface. 11(101):20140726.