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Work in the lab focuses on the force generating mechanisms of kinesin molecular motors and their microtubule tracks.
These mechanisms drive much of the active self-organisation behaviour of complex living cells and understanding them is important both for fundamental science and for the development of improved chemical biology approaches to a range of important medical and agricultural problems.
Prakash et al (doi.org/10.1101/2025...), emerging from a happy & ongoing multilab collaboration, shows that a mix of human α1β3 and α1β4 tubulins assembles in vitro into segmented microtubules in which the segments have different protofilament numbers, and are recognized by different MAPS.
— robcro55.bsky.social (@robcro55.bsky.social) March 14, 2025 at 8:41 AM
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Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
— robcro55.bsky.social (@robcro55.bsky.social) February 12, 2025 at 4:22 PM
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