10 07 2026 We report that mutating the interPF interface in human MTs allows them to assemble in GDP. We propose that tubulin molecules are captured indiscriminately at MT tips but then retained only if they can bind stably to a lateral nearest-neighbour. [Link]

 

18 02 2026 ATPγS unbiasing now published! [Link]

 

01 05 2025 We used ATPγS to reveal a previously-occult kinesin state. In the Await-Isomerisation (AI) state, ATP is bound and stepping is activated, but NL docking and hydrolysis are inhibited. [Link]

 

13 03 2025 Our single isotype human tubulins can assemble into segmented microtubules in which the different segments prefer specific MAPS. [Link]

 

02 02 2025 We review the possibility that structural switching in the microtubule lattice elaborates on a more ancient protofilament-level switch. [Link]

 

Our work asks about the force generating mechanisms of kinesin molecular motors and their microtubule tracks.

These mechanisms drive much of the active self-organisation behaviour of complex living cells. Understanding them is important both for fundamental science and for the development of improved chemical biology approaches to a range of important medical and agricultural problems.