Research

Research Interests |

Our research spans over multiple scales of organization: we explore biochemical and mechanical processes at tissue, single cell and down to gene expression levels with the ultimate aim to link these events in space and time. We focus our efforts on developmental programs that regulate tissue formation during zebrafish gastrulation including tissue morphogenesis, collective cell migration, signaling from cell-cell adhesions to the nucleus and gene expression events involved in cell behaviour and fate specification.


research

Research Methods |

Our research encompasses methodologies and technologies such as:

  • quantitative live cell imaging (confocal, spinning disk, light sheet)
  • optogenetics
  • embryological methods (ISH, transplantations)
  • in vitro reconstitution assays (micropatterning, supported lipid bilayers)
  • biophysical tools (microfluidics, laser ablation)
  • transcriptomics (scRNA sequencing, multiplexed smFISH)
  • gene editing (Crispr/Cas9)
  • theoretical modelling (collective motion, biomechanics)

Current Collaborators |

Our projects are highly interdisciplinary and we are working closely with national and international collaborators including:
Till Brettschneider (Warwick Computer Science) | Computational Image Analysis
Jerome Charmet (Warwick Manufacturing Group), Melikhan Tanyeri (Duquesne University, US), Vasily Kantsler (Warwick Physics) | Microfluidics, Microfabrication
Kok Hao Chen (Singapore Genomic Institute) | Transcriptomics
Darius Koester (Warwick Medical School) | Biophysics
Matthew Turner (Warwick Physics) | Modelling
Verena Ruprecht (CRG Barcelona, ES) | Cell Migration
Anne Straube (Warwick Medical School) | Microtubule dynamics

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